韦广红
发布时间: 2013-08-22     文章作者:     访问次数: 34223

 

 

 

韦广红

 

教授

1998年beat365手机官方网站博士

电话:+86-21-31249023

Emailghwei@fudan.edu.cn

个人网站/Website链接/Link

 

主要经历:
1995.91998.6beat365手机官方网站物理系凝聚态物理专业,博士

1998.72001.9beat365手机官方网站材料系讲师

2001.92005.8加拿大蒙特利尔大学物理系、美国加州大学圣芭芭拉分校化学和生物化学系博士后

2005.9—至今beat365手机官方网站物理系副教授、教授、博士生导师

 

教学与研究领域:

教学:主讲大学物理物理生物学课程。

研究领域:计算物理生物

研究方向:蛋白质/多肽聚集、自组装、蛋白-生物膜相互作用、蛋白-纳米颗粒相互作用、及天然小分子调控蛋白聚集微观机理的计算机模拟研究。

研究意义:多肽自组装一方面与阿兹海默氏症、帕金森症和渐冻人症等多种淀粉样变性病密切相关,另一方面在生物纳米材料设计方面有重要应用。因此,对多肽聚集和自组装问题的研究,将有助于了解蛋白病理性聚集和自组装的微观机制,为设计疾病相关治疗药物及新型生物纳米材料提供线索和理论基础。


 

Guanghong Wei

 

Professor

Ph.D. (1998), Fudan University

 

Research Interests:
Computational study   of peptide folding, misfolding, aggregation; and ordered nanostructure   formation; peptide-membrane interactions; protein-nanoparticle interactions.

 

Selected   Publications:
1. G Wei, W Xi, R Nussinov, and B Ma. Protein ensembles: how does nature harness thermodynamic fluctuations for life? The diverse functional roles of conformational ensembles in the cell. Chem Rev, 116: 6516 (2016).

2. C Guo, ZA Arnon, R Qi, Q Zhang, L Adler-Abramovich, E Gazit, and G Wei. Expanding the nanoarchitectural diversity through aromatic di- and tri-peptide coassembly: nanostructures and molecular mechanisms. ACS Nano, 10: 8316, (2016).

3. Y Li, Z Qian, L Ma, S Hu, D Nong, C Xu, F Ye, Y Lu, G Wei, and M Li. Single molecule visualization of dynamic transitions of pore-forming peptides among multiple transmembrane positions. Nat Commun, 7: 12906 (2016).

4. L Niu, L Liu, W Xi, Q Han, Q Li, Y Yu, Q Huang, F Qu, M Xu, Y Li, H Du, R Yang, J Cramer, KV Gothelf, M Dong, F Besenbacher, Q Zeng, C Wang, G Wei, and Y Yang. Synergistic inhibitory effect of peptide–organic coassemblies on amyloid aggregation. ACS Nano, 10: 4143 (2016).

5. B Dai, D Li, W Xi, F Luo, X Zhang, M Zou, M Cao, J Hu, W Wang, G Wei, Y Zhang, and C Liu. Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier. Proc Natl Acad Sci U S A, 112: 2996 (2015).

6. Y Luo, B Ma, R Nussinov, G Wei. Structural insight into tau protein’s paradox of intrinsically disordered behavior, self-acetylation activity, and aggregation. J Phys Chem Lett, 5: 3026 (2014).

7. X Mao, Y Guo, Y Luo, L Niu, L Liu, X Ma, H Wang, Y Yang, G Wei, C Wang. Sequence effects on peptide assembly characteristics observed by using scanning tunneling microscopy. J Am Chem Soc, 135: 2181 (2013).

8. C Guo, Y Luo, R Zhou, and G Wei. Probing the self-assembly mechanism of diphenylalanine-based peptide nanovesicles and nanotubes. ACS Nano, 6: 3907 (2012).


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